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Route Illustration - Actual route may differ
Cruise

16-Night Panama Canal Cruise on Seven Seas Grandeur

Slice through Central America via the most famous canal in the world. With more than 900 species of birds, 10,000 species of plants, 1,350 plants and animals indigenous to the country and more species of mammals and amphibians than any other Central American country, Panama has one of the richest tropical environments on earth. Follow the footsteps of the conquistadors and immerse yourself in Panama's rich ecological and cultural diversity.
As low as $16,949 per person
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Rachael Roberts
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Departure Port

  • Miami, Florida

Debarkation Port

  • Los Angeles, California

Destination

  • Panama Canal

Voyage at a glance

16-night sailing aboard Seven Seas Grandeur.

ShipSeven Seas Grandeur
Sailing datesTuesday, December 29, 2026 – Thursday, January 14, 2027
RouteMiami, Florida → Los Angeles, California
Recently found from$16,949 per person

Advisor Consultation

Get personalized guidance and book your trip with confidence.

Schedule My Consultation

Book with a professional travel advisor and you may unlock more than what appears in a standard online search. Depending on the supplier and trip, your advisor may have access to preferred or agency-negotiated group rates, special promotions, upgrades, onboard or resort credits, and other added-value benefits that are not always available through direct booking.

During our consultation, we may ask for a few details—such as your country or state of residence, ZIP code, age eligibility, military status, past-guest history, or loyalty memberships. These details can help us identify fares and benefits you may qualify for and compare them against publicly available options.

Not every offer applies to every traveler, and availability varies by supplier, destination, sailing, travel dates, and eligibility. But the more we know about your trip and the qualifications that may apply to you, the more thoroughly we can search for opportunities to enhance your vacation and help you secure the best available overall value not just the first price you see online.

Recent price found was as low as: $16,949 per person. Port charges, taxes, and fees of $1,796 USD included

Itinerary Overview

Day 1 · Miami, Florida

Miami, Florida

Depart 5:00 pm

Discover the cosmopolitan beauty of Miami along Florida's fabled Gold Coast. Stroll through carefully preserved Art Deco neighborhoods and witness the trendy lifestyle that is South Beach. Enjoy open-air shopping in the Bayside Marketplace and shop for a bite to eat in Coconut Grove, with its harborside cafes and quaint, artistic settings.

Day 2 · CRUISING THE STRAITS OF FLORIDA

CRUISING THE STRAITS OF FLORIDA

Day 3 · Georgetown, Grand Cayman, Cayman Islands

Georgetown, Grand Cayman, Cayman Islands

Arrive 9:00 am · Depart 4:00 pm

Survey the neatly shuttered shops for bargains, or the twisted rock formations known as "Hell." But there's nothing hellish about the white-sand heaven of Seven Mile Beach. Sample the rum distilled here and be sure to visit the world's only sea turtle farm.

Day 4 · CRUISING THE CARIBBEAN SEA

CRUISING THE CARIBBEAN SEA

Day 5 · Cartagena, Spain

Cartagena, Spain

Arrive 7:00 am · Depart 2:00 pm

...The weather almost never becomes too hot or uncomfortable, and the sights and smells of the land are marvelous...It is also Spain's main naval base...The landscaped squares of Cartagena are so magnificent that you can spend hours just sitting and looking...The buildings and religious structures of the city add to its wonderful culture, and a walking tour of Cartagena is great fun.

Day 6 · PANAMA CANAL TRANSIT

PANAMA CANAL TRANSIT

Day 7 · CRUISING THE PACIFIC OCEAN

CRUISING THE PACIFIC OCEAN

Day 8 · Puntarenas, Costa Rica

Puntarenas, Costa Rica

Arrive 6:00 am · Depart 7:00 pm

Day 9 · CRUISING THE PACIFIC OCEAN

CRUISING THE PACIFIC OCEAN

Day 10 · Puerto Quetzal, Guatemala

Puerto Quetzal, Guatemala

Arrive 7:00 am · Depart 7:00 pm

Puerto Quetzal has become the destination of choice for historians interested in looking at ancient Mayan ruins. The ancient city of Tikal is nearby, and its ruins are remarkably well preserved. Once you've seen the ruins, take it easy along Guatemala's Pacific shore. The beaches here attract Guatemalans from all over the country.

Day 11 · CRUISING THE PACIFIC OCEAN

CRUISING THE PACIFIC OCEAN

Day 12 · Acapulco, Mexico

Acapulco, Mexico

Arrive 8:00 am · Depart 5:00 pm

Whitewashed villas ring magnificent Acapulco Bay, forming an unforgettable spectacle. View Mexico's premier Pacific playground from the scenic highway above the harbor, then stop to enjoy Acapulco's most famous attraction: the daredevil cliff-divers of La Quebrada, who pray at a nearby chapel, then plunge from the 130-foot-high cliffs.

Day 13 · CRUISING THE PACIFIC OCEAN

CRUISING THE PACIFIC OCEAN

Day 14 · Cabo San Lucas, Mexico

Cabo San Lucas, Mexico

Arrive 10:00 am · Depart 6:00 pm

Sail past Los Arcos, the soaring rock archway at the extreme southern tip of Baja California that guards Cabo's perfect harbor. This idyllic bay once sheltered treasure ships from the Orient, and pirate brigs bent on those treasures. Now Cabo caters to an international vacation set, and has a strong artistic tradition famous for its black-coral jewelry.

Day 15 · CRUISING THE PACIFIC OCEAN

CRUISING THE PACIFIC OCEAN

Day 16 · San Diego, California

San Diego, California

Depart 10:00 pm

Blessed with a sunny climate and a fine natural harbor, San Diego has grown from a Spanish mission into a thriving town. With two universities, a world-class zoo and safari park, the famous Hotel Del Coronado and the museums and attractions of Balboa Park, it's well worth exploring.

Day 17 · Los Angeles, California

Los Angeles, California

Arrive 7:00 am

Sprawling between the mountains and the beaches, Los Angeles is quintessential California. Whether your taste runs to fashionable Beverly Hills, the mega-entertainment of the movie studios, or the sizzle of homestyle Mexican food on Olvera Street, the city of angels is worth exploring.

Route Illustration - Actual route may differ
Route Illustration - Actual route may differ

Highlights

Sail aboard Seven Seas Grandeur.
Travel from 2026-12-29 through 2027-01-14.
Visit Miami, Florida, Georgetown, Grand Cayman, Cayman Islands, Cartagena, Spain, Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Cabo San Lucas, Mexico, San Diego, California, Los Angeles, California.
Recently found pricing

Cabin pricing snapshot

Recent cabin prices we found for this sailing. Pricing is shown per person and may change at any time.

Cabin Types
  • Inside
    Not currently available — cabin inventory may change.
  • Oceanview
    Not currently available — cabin inventory may change.
  • Balcony
    Not currently available — cabin inventory may change.
  • SuiteRecently found from $16,949 per person
    Port charges, taxes, and fees of $1,796 USD included

Final taxes, fees, promotions, or availability can change.

Additional Information

Price, availability, taxes, fees, promotions, occupancy requirements, and final cabin availability can change until booked. When you book travel through a professional travel advisor, suppliers often provide exclusive value-adds, upgrades, and promotions that are unavailable when booking directly online. These unadvertised or agency-exclusive perks vary by vendor and destination.

Tags

allcruisePanama CanalRegent Seven Seas CruisesSeven Seas GrandeurMiami, Florida