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Route Illustration - Actual route may differ
Cruise

18-Night Panama Canal Cruise on Azamara Quest

Slice through Central America via the most famous canal in the world. With more than 900 species of birds, 10,000 species of plants, 1,350 plants and animals indigenous to the country and more species of mammals and amphibians than any other Central American country, Panama has one of the richest tropical environments on earth. Follow the footsteps of the conquistadors and immerse yourself in Panama's rich ecological and cultural diversity.
As low as $3,939 per person
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Rachael Roberts
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Departure Port

  • Miami, Florida

Debarkation Port

  • San Francisco, California

Destination

  • Panama Canal

Voyage at a glance

18-night sailing aboard Azamara Quest.

ShipAzamara Quest
Sailing datesFriday, December 18, 2026 – Tuesday, January 5, 2027
RouteMiami, Florida → San Francisco, California
Recently found from$3,939 per person

Advisor Consultation

Get personalized guidance and book your trip with confidence.

Schedule My Consultation

Book with a professional travel advisor and you may unlock more than what appears in a standard online search. Depending on the supplier and trip, your advisor may have access to preferred or agency-negotiated group rates, special promotions, upgrades, onboard or resort credits, and other added-value benefits that are not always available through direct booking.

During our consultation, we may ask for a few details—such as your country or state of residence, ZIP code, age eligibility, military status, past-guest history, or loyalty memberships. These details can help us identify fares and benefits you may qualify for and compare them against publicly available options.

Not every offer applies to every traveler, and availability varies by supplier, destination, sailing, travel dates, and eligibility. But the more we know about your trip and the qualifications that may apply to you, the more thoroughly we can search for opportunities to enhance your vacation and help you secure the best available overall value not just the first price you see online.

Recent price found was as low as: $3,939 per person. Taxes and fees of $770 USD included. Port charges of $999 USD included.

Itinerary Overview

Day 1 · Miami, Florida

Miami, Florida

Depart 5:00 pm

Discover the cosmopolitan beauty of Miami along Florida's fabled Gold Coast. Stroll through carefully preserved Art Deco neighborhoods and witness the trendy lifestyle that is South Beach. Enjoy open-air shopping in the Bayside Marketplace and shop for a bite to eat in Coconut Grove, with its harborside cafes and quaint, artistic settings.

Day 2 · AT SEA

AT SEA

Day 3 · AT SEA

AT SEA

Arrive 3:00 pm

Day 4 · Cabo Rojo, Dominican Republic

Cabo Rojo, Dominican Republic

Arrive 8:00 am · Depart 6:00 pm

Cabo Rojo is a picturesque town located on the southwestern coast of the Dominican Republic, known for its stunning beaches, vibrant culture, and natural beauty. The area is famous for its dramatic cliffs, crystal-clear waters, and white sandy beaches, making it a popular destination for relaxation and water sports. Visitors can explore the nearby Cabo Rojo National Park, which is home to diverse wildlife and beautiful landscapes, including salt flats and mangroves. The town is also rich in local culture, offering delicious seafood, lively music, and a warm, welcoming atmosphere. Cabo Rojo is an ideal spot for those looking to experience the beauty and charm of the Dominican Republic.

Day 5 · AT SEA

AT SEA

Day 6 · Cartagena, Colombia

Cartagena, Colombia

Arrive 7:00 am · Depart 1:00 pm

Charming Cartagena is one of the most fascinating towns in South America. The old city, almost completely surrounded by lagoons, bays and the Caribbean Sea, is still girded by its 17th-century fortifications. Once these guarded the gold and treasures of the New World, bound for Spain; now they shelter ornate churches and convents, the dramatic Palace of the Inquisition, and other historic gems.

Day 7 · Panama Canal, Panama

Panama Canal, Panama

Arrive 5:00 am · Depart 5:00 pm

Spend an unforgettable day cruising the Panama Canal, a fifty-one-mile waterway through the rainforest that is one of the world's engineering masterpieces. The ship glides down the canal with inches to spare, through locks that raise and lower it like a toy. Along the way it crosses enormous Gatun Lake, and the amazing Gaillard Cut, blasted out of a solid mountainside.

Day 8 · AT SEA

AT SEA

Day 9 · Puntarenas, Costa Rica

Puntarenas, Costa Rica

Arrive 8:00 am · Depart 8:00 pm

Day 10 · AT SEA

AT SEA

Day 11 · Puerto Quetzal, Guatemala

Puerto Quetzal, Guatemala

Arrive 8:00 am · Depart 4:00 pm

Puerto Quetzal has become the destination of choice for historians interested in looking at ancient Mayan ruins. The ancient city of Tikal is nearby, and its ruins are remarkably well preserved. Once you've seen the ruins, take it easy along Guatemala's Pacific shore. The beaches here attract Guatemalans from all over the country.

Day 12 · AT SEA

AT SEA

Day 13 · AT SEA

AT SEA

Arrive 3:00 pm

Day 14 · Puerto Vallarta, Mexico

Puerto Vallarta, Mexico

Arrive 9:00 am · Depart 11:00 pm

Hollywood discovered this little fishing village back in the 1960's, and since then luxury resorts and bougainvillea-covered villas have flourished in the delightful seaside climate. Yet hints of past tranquility remain: cobbled courtyards where the locals hold their markets, and superb sport-fishing just offshore.

Day 15 · AT SEA

AT SEA

Day 16 · AT SEA

AT SEA

Arrive 3:00 pm

Day 17 · San Diego, California

San Diego, California

Arrive 3:00 pm · Depart 10:00 pm

Blessed with a sunny climate and a fine natural harbor, San Diego has grown from a Spanish mission into a thriving town. With two universities, a world-class zoo and safari park, the famous Hotel Del Coronado and the museums and attractions of Balboa Park, it's well worth exploring.

Day 18 · AT SEA

AT SEA

Day 19 · San Francisco, California

San Francisco, California

Arrive 6:00 am

Sailing under the Golden Gate Bridge and into San Francisco's broad bay will surely be a highlight of your cruising life. Once docked along the Embarcadero, you're just a short walk from Fisherman's Wharf, Chinatown, North Beach and other attractions that make this one of the world's favorite cities. The scenic Napa Valley wine country is nearby, too.

Day 19 · San Francisco, California

San Francisco, California

Arrive 6:30 am

Sailing under the Golden Gate Bridge and into San Francisco's broad bay will surely be a highlight of your cruising life. Once docked along the Embarcadero, you're just a short walk from Fisherman's Wharf, Chinatown, North Beach and other attractions that make this one of the world's favorite cities. The scenic Napa Valley wine country is nearby, too.

Route Illustration - Actual route may differ
Route Illustration - Actual route may differ

Highlights

Sail aboard Azamara Quest.
Travel from 2026-12-18 through 2027-01-05.
Visit Miami, Florida, Cabo Rojo, Dominican Republic, Cartagena, Colombia, Panama Canal, Panama, Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California.
Recently found pricing

Cabin pricing snapshot

Recent cabin prices we found for this sailing. Pricing is shown per person and may change at any time.

Cabin Types
  • InsideRecently found from $3,939 per person
    Taxes and fees of $770 USD included. Port charges of $999 USD included.
  • OceanviewRecently found from $4,539 per person
    Taxes and fees of $770 USD included. Port charges of $999 USD included.
  • Balcony
    Not currently available — cabin inventory may change.
  • Suite
    Not currently available — cabin inventory may change.

Final taxes, fees, promotions, or availability can change.

Additional Information

Price, availability, taxes, fees, promotions, occupancy requirements, and final cabin availability can change until booked. When you book travel through a professional travel advisor, suppliers often provide exclusive value-adds, upgrades, and promotions that are unavailable when booking directly online. These unadvertised or agency-exclusive perks vary by vendor and destination.

Tags

allcruisePanama CanalAzamaraAzamara QuestMiami, Florida