Slice through Central America via the most famous canal in the world. With more than 900 species of birds, 10,000 species of plants, 1,350 plants and animals indigenous to the country and more species of mammals and amphibians than any other Central American country, Panama has one of the richest tropical environments on earth. Follow the footsteps of the conquistadors and immerse yourself in Panama's rich ecological and cultural diversity.
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Not every offer applies to every traveler, and availability varies by supplier, destination, sailing, travel dates, and eligibility. But the more we know about your trip and the qualifications that may apply to you, the more thoroughly we can search for opportunities to enhance your vacation and help you secure the best available overall value not just the first price you see online.
Recent price found was as low as: $1,899 per person. Taxes and fees of $700 USD included. Port charges of $400 USD included.
Itinerary Overview
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Day 1 · San Diego, California
San Diego, California
Depart 4:00 pm
Blessed with a sunny climate and a fine natural harbor, San Diego has grown from a Spanish mission into a thriving town. With two universities, a world-class zoo and safari park, the famous Hotel Del Coronado and the museums and attractions of Balboa Park, it's well worth exploring.
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Day 2 · AT SEA
AT SEA
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Day 3 · AT SEA
AT SEA
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Day 4 · Puerto Vallarta, Mexico
Puerto Vallarta, Mexico
Arrive 8:00 am · Depart 5:00 pm
Hollywood discovered this little fishing village back in the 1960's, and since then luxury resorts and bougainvillea-covered villas have flourished in the delightful seaside climate. Yet hints of past tranquility remain: cobbled courtyards where the locals hold their markets, and superb sport-fishing just offshore.
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Day 5 · AT SEA
AT SEA
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Day 6 · Huatulco, Mexico
Huatulco, Mexico
Arrive 10:00 am · Depart 5:00 pm
The entire community is, in essence, a beach, so you will never be far from the sparkling sea and the warm, shimmering sand.There are a couple of outstanding restaurants in the vicinity, and the shopping here is limited but still enjoyable.The Museo de Artesanias Oxaquenas is an extraordinary museum where you can watch artistic geniuses at work.
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Day 7 · Puerto Chiapas, Mexico
Puerto Chiapas, Mexico
Arrive 8:00 am · Depart 5:00 pm
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Day 8 · Puerto Quetzal, Guatemala
Puerto Quetzal, Guatemala
Arrive 6:00 am · Depart 8:00 pm
Puerto Quetzal has become the destination of choice for historians interested in looking at ancient Mayan ruins. The ancient city of Tikal is nearby, and its ruins are remarkably well preserved. Once you've seen the ruins, take it easy along Guatemala's Pacific shore. The beaches here attract Guatemalans from all over the country.
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Day 9 · Acajutla, El Salvador
Acajutla, El Salvador
Arrive 7:00 am · Depart 5:00 pm
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Day 10 · AT SEA
AT SEA
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Day 11 · AT SEA
AT SEA
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Day 12 · Panama Canal, Panama
Panama Canal, Panama
Arrive 5:00 am · Depart 5:00 am
Spend an unforgettable day cruising the Panama Canal, a fifty-one-mile waterway through the rainforest that is one of the world's engineering masterpieces. The ship glides down the canal with inches to spare, through locks that raise and lower it like a toy. Along the way it crosses enormous Gatun Lake, and the amazing Gaillard Cut, blasted out of a solid mountainside.
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Day 12 · Panama Canal, Panama
Panama Canal, Panama
Spend an unforgettable day cruising the Panama Canal, a fifty-one-mile waterway through the rainforest that is one of the world's engineering masterpieces. The ship glides down the canal with inches to spare, through locks that raise and lower it like a toy. Along the way it crosses enormous Gatun Lake, and the amazing Gaillard Cut, blasted out of a solid mountainside.
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Day 12 · Panama Canal, Panama
Panama Canal, Panama
Arrive 7:00 pm · Depart 7:00 pm
Spend an unforgettable day cruising the Panama Canal, a fifty-one-mile waterway through the rainforest that is one of the world's engineering masterpieces. The ship glides down the canal with inches to spare, through locks that raise and lower it like a toy. Along the way it crosses enormous Gatun Lake, and the amazing Gaillard Cut, blasted out of a solid mountainside.
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Day 13 · Cartagena, Colombia
Cartagena, Colombia
Arrive 12:00 pm · Depart 6:00 pm
Charming Cartagena is one of the most fascinating towns in South America. The old city, almost completely surrounded by lagoons, bays and the Caribbean Sea, is still girded by its 17th-century fortifications. Once these guarded the gold and treasures of the New World, bound for Spain; now they shelter ornate churches and convents, the dramatic Palace of the Inquisition, and other historic gems.
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Day 14 · AT SEA
AT SEA
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Day 15 · AT SEA
AT SEA
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Day 16 · Half Moon Cay (Little San Salvador Island), Bahama
Half Moon Cay (Little San Salvador Island), Bahama
Arrive 8:00 am · Depart 2:00 pm
Half Moon Cay has the attraction of other private islands plus some! This 2500 acre island, prides itself in maintaining the natural ecology; it protects 2400 of its acres by keeping them wholly unspoiled. Located one hundred miles SE of Nassau, its large protected bay used to be a famous refuge for pirates (or as famous as a pirate refuge can get). Enjoy nature activities, beach fun, or just swing in the hammock to the island steel band. Make sure to take at least one dip in the beach which is only chest deep 60 ft out!
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Day 17 · Fort Lauderdale (Port Everglades), Florida
Fort Lauderdale (Port Everglades), Florida
Arrive 7:00 am
Originally a fort built by the U.S. Army in 1838 during the Second Seminole War, Fort Lauderdale welcomes visitors with broad, palm-fringed beaches and an easy pace of life. Stroll along fashionable Las Olas Boulevard with its stylish shops or enjoy a sightseeing cruise through the city''s canals, boasting more waterways than Venice. Or, venture out and explore the cosmopolitan city of Palm Beach, or the wildlife sanctuary of the Everglades.
Route Illustration - Actual route may differ
Highlights
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Sail aboard Nieuw Amsterdam.
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Travel from 2026-10-02 through 2026-10-18.
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Visit San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Panama Canal, Panama, Cartagena, Colombia, Half Moon Cay (Little San Salvador Island), Bahama, Fort Lauderdale (Port Everglades), Florida.
Recently found pricing
Cabin pricing snapshot
Recent cabin prices we found for this sailing. Pricing is shown per person and may change at any time.
Cabin Types
InsideRecently found from $1,899 per person
Taxes and fees of $700 USD included. Port charges of $400 USD included.
OceanviewRecently found from $1,979 per person
Taxes and fees of $700 USD included. Port charges of $400 USD included.
BalconyRecently found from $2,199 per person
Taxes and fees of $700 USD included. Port charges of $400 USD included.
Suite
Not currently available — cabin inventory may change.
Final taxes, fees, promotions, or availability can change.
Additional Information
Price, availability, taxes, fees, promotions, occupancy requirements, and final cabin availability can change until booked. When you book travel through a professional travel advisor, suppliers often provide exclusive value-adds, upgrades, and promotions that are unavailable when booking directly online. These unadvertised or agency-exclusive perks vary by vendor and destination.
Gallery
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Route Illustration - Actual route may differ
Tags
allcruisePanama CanalHolland America LineNieuw AmsterdamSan Diego, California